Retatrutide titration schedule
The whole ladder, converted into the exact number of units to draw at every stage. Change the vial or the water and it recalculates.
The schedule
| Stage | Weekly dose | Draw | U-100 units | Vials used by end |
|---|---|---|---|---|
| Weeks 1–4 | 2 mg | 0.4 mL | 40 units | 0.8 |
| Weeks 5–8 | 4 mg | 0.8 mL | 80 units | 2.4 |
| Weeks 9–12 | 6 mg | 1.2 mL | 120 units | 4.8 |
| Weeks 13–16 | 8 mg | 1.6 mL | 160 units | 8.0 |
| Weeks 17–20 | 10 mg | 2 mL | 200 units | 12.0 |
| Weeks 21–24 | 12 mg | 2.4 mL | 240 units | 16.8 |
Based on a 10 mg vial with 2 mL of bacteriostatic water (5 mg/mL) on a U-100 syringe, stepping every 4 weeks. Change any of that and the units change, so run your own numbers in the calculator above.
How to read it
Retatrutide is investigational and has no licensed titration schedule, because it has never been approved. The ladder below is the pattern most commonly reported: start at 2 mg weekly and step up 2 mg every four weeks. Some people step every six or eight weeks instead, and plenty stop well before 12 mg.
The point of a slow ladder is tolerability. Stepping faster than your side effects allow is the single most common reason people abandon a GLP-1 entirely.
Calculators by compound
Common questions
- How long does a full retatrutide titration take?
- Stepping 2 mg every four weeks from 2 mg to 12 mg is six stages, which is 24 weeks. Slower steps of six weeks make it 36 weeks.
- How many vials do I need for a full titration?
- At a 10 mg vial, stepping 2 mg every four weeks to 12 mg, the whole ladder uses about 16.8 vials. The early stages are cheap and the top of the ladder is where the cost sits.
- Do I have to reach 12 mg?
- No. The ladder is a ceiling, not a target. Many reported protocols hold at 4, 6 or 8 mg indefinitely.