Semaglutide titration schedule
The whole ladder, converted into the exact number of units to draw at every stage. Change the vial or the water and it recalculates.
The schedule
| Stage | Weekly dose | Draw | U-100 units | Vials used by end |
|---|---|---|---|---|
| Weeks 1–4 | 0.25 mg | 0.1 mL | 10 units | 0.2 |
| Weeks 5–8 | 0.5 mg | 0.2 mL | 20 units | 0.6 |
| Weeks 9–12 | 1 mg | 0.4 mL | 40 units | 1.4 |
| Weeks 13–16 | 1.7 mg | 0.68 mL | 68 units | 2.8 |
| Weeks 17–20 | 2.4 mg | 0.96 mL | 96 units | 4.7 |
Based on a 5 mg vial with 2 mL of bacteriostatic water (2.5 mg/mL) on a U-100 syringe, stepping every 4 weeks. Change any of that and the units change, so run your own numbers in the calculator above.
How to read it
Semaglutide has a licensed ladder: 0.25 mg weekly for four weeks, then 0.5 mg, 1.0 mg, 1.7 mg and 2.4 mg, each held for four weeks before the next step. As with tirzepatide, the first rung is a starting dose for tolerance rather than a maintenance dose.
The doses are small enough that the water volume matters more here than for any other compound. A 5 mg vial in 2 mL puts 0.25 mg at 10 units. The same vial in 1 mL puts it at 5 units, where a one-unit misread is a 20 percent dosing error.
Calculators by compound
Common questions
- What is the standard semaglutide titration schedule?
- 0.25 mg once weekly for four weeks, then 0.5 mg, 1.0 mg, 1.7 mg and 2.4 mg, stepping every four weeks as tolerated.
- How many units is 0.25 mg of semaglutide?
- In a 5 mg vial with 2 mL of bacteriostatic water, which is 2.5 mg/mL, 0.25 mg is 0.1 mL, or 10 units on a U-100 syringe.
- What if a step is intolerable?
- The licensed guidance is to hold at the previous dose for longer rather than push through. The ladder is a maximum pace, not a schedule you owe anyone.